Dah tiga hari ini aq ga sempet istirahat dengan tenang. Malem jaga warnet, paginya langsung ke lab ngerjain proyeknya dosen sampe sore. Sore pulang mandi bentar, habis itu ke lab lagi sampe jam 23.30 and ga sempet pulang tapi langsung ke warnet……. Duh capeknya……….
Ketika Si “Dia” Minta Di Pinang
Hari ini adalah hari yang begitu membahagiakan. Walaupun sejujurnya ngga begitu bahagia. Gimana tidak, sudah hampir tiga tahun aku “Jalan” sama si “Imut” (panggilan sayangq sama Dia). Dia dah mngutarakan supaya di pinang sebelum Dia berumur 25 tahun. Sedangkan sekarang Dia dah berumur 22 tahun…… jadi sekarang aku cuma punya waktu 2 tahun lagi buat mempersiapkan semuanya.
Yach.. itulah yang membuatku bahagia dan juga harus berusaha super keras untuk memenuhi cita-cita kami. So …… mohon doa dari kalian yach…..
Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling
Oncogene (2007) 26, 6968–6978; doi:10.1038/sj.onc.1210503; published online 7 May 2007
K Shtiegman1, B S Kochupurakkal1, Y Zwang1, G Pines1, A Starr2, A Vexler2, A Citri1, M Katz1, S Lavi1, Y Ben-Basat1, S Benjamin3, S Corso4, J Gan1, R B Yosef2, S Giordano4 and Y Yarden1
- 1Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel
- 2Division of Oncology, Tel Aviv Sourasky Medical Center and Tel Aviv University School of Medicine, Ramat Aviv, Israel
- 3Department of Cell Research and Immunology, Tel Aviv University, Ramat Aviv, Israel
- 4Division of Molecular Oncology, Department of Oncological Sciences, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Torino, Italy
Correspondence: Professor Y Yarden, Department of Biological Regulation, Room 302, Candiotty Building, The Weizmann Institute of Science, 1 Hertzl Street, Rehovot 76100, Israel. E-mail: yosef.yarden@weizmann.ac.il
Received 12 October 2006; Revised 12 March 2007; Accepted 23 March 2007; Published online 7 May 2007.
Abstract
Several distinct mutations within the kinase domain of the epidermal growth factor receptor (EGFR) are associated with non-small cell lung cancer, but mechanisms underlying their oncogenic potential are incompletely understood. Although normally ligand-induced kinase activation targets EGFR to Cbl-mediated receptor ubiquitinylation and subsequent degradation in lysosomes, we report that certain EGFR mutants escape this regulation. Defective endocytosis characterizes a deletion mutant of EGFR, as well as a point mutant (L858R-EGFR), whose association with c-Cbl and ubiquitinylation are impaired. Our data raise the possibility that refractoriness of L858R-EGFR to downregulation is due to enhanced heterodimerization with the oncogene product HER2, which leads to persistent stimulation.
Continue reading “Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling”
Crystallizing the Early Cosmos
Blowing hot and cold.
Zones of temperature variations (hot in red and cold in blue) in a computer simulation of the cosmic background radiation signify a texture in the early universe.
Credit: V. Travieso and N. Turok
By Phil Berardelli
ScienceNOW Daily News
25 October 2007
A new analysis of the afterglow of the big bang supports a novel theory of how the universe took shape, theoretical physicists say. The existence of a curious cold spot in the sky suggests that the cosmos quickly sported flaws that resulted in the formation of the first stars and galaxies.
Journal of Human Hypertension (2007) 21, 861–867; doi:10.1038/sj.jhh.1002244; published online 21 June 2007
Journal of Human Hypertension (2007) 21, 861–867; doi:10.1038/sj.jhh.1002244; published online 21 June 2007
Matrix metalloproteinase-9 polymorphism contributes to blood pressure and arterial stiffness in essential hypertension
Matrix metalloproteinase-9 polymorphism contributes to blood pressure and arterial stiffness in essential hypertension
S Zhou1, J Feely1,2, J P Spiers1 and A Mahmud1,2
1Department of Pharmacology and Therapeutics, Trinity College Dublin, Dublin, Ireland
2Hypertension Clinic, St James’s Hospital, Dublin, Ireland
Correspondence: Dr A Mahmud, Department of Pharmacology and Therapeutics, Trinity Centre for Health Sciences, St James’s Hospital, Dublin 8, Ireland. E-mail: mahmuda@tcd.ie
Received 19 January 2007; Revised 29 April 2007; Accepted 5 May 2007; Published online 21 June 2007.
Abstract
Arterial stiffness is an independent predictor of cardiovascular events in a hypertensive population. Serum levels of matrix metalloproteinase (MMP)-9 are associated with arterial stiffness and predict cardiovascular risk. We investigated the role of MMP-9 polymorphism -1562C>T on blood pressure (BP) and arterial stiffness in a newly diagnosed hypertensive population. Untreated hypertensive patients (n=215, mean age 4613 years) were studied. Supine BP, carotid-femoral pulse wave velocity (PWV) and augmentation index were assessed. Serum biochemistry and plasma MMP-9 concentrations were measured and genotyping performed following extraction of genomic DNA. BP, aortic PWV and serum MMP-9 levels were significantly higher in T-allele carriers of the -1562C>T polymorphism with a significant gene–dose effect (PT polymorphism emerged as an independent predictor of systolic BP (R2=0.25, P<0.0001), diastolic BP (R2=0.16, P<0.0001) and PWV (R2=0.47,P<0.0001). This is the first study to show the effect of MMP-9 polymorphism on BP and aortic stiffness in a hypertensive population. These results suggest that hypertensive patients carrying the T allele may be at increased risk of cardiovascular events.
Keywords: MMP-9 gene polymorphism, arterial stiffness, aortic pulse wave velocity, augmentation index, MMP-9 levels
Source : Journal of Human Hypertension
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