Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling

Oncogene (2007) 26, 6968–6978; doi:10.1038/sj.onc.1210503; published online 7 May 2007
K Shtiegman1, B S Kochupurakkal1, Y Zwang1, G Pines1, A Starr2, A Vexler2, A Citri1, M Katz1, S Lavi1, Y Ben-Basat1, S Benjamin3, S Corso4, J Gan1, R B Yosef2, S Giordano4 and Y Yarden1

1Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel
2Division of [...]

Crystallizing the Early Cosmos

 
Blowing hot and cold.
Zones of temperature variations (hot in red and cold in blue) in a computer simulation of the cosmic background radiation signify a texture in the early universe.
Credit: V. Travieso and N. Turok
By Phil Berardelli
ScienceNOW Daily News
25 October 2007

A new analysis of the afterglow of the big bang supports a [...]

Journal of Human Hypertension (2007) 21, 861–867; doi:10.1038/sj.jhh.1002244; published online 21 June 2007

Journal of Human Hypertension (2007) 21, 861–867; doi:10.1038/sj.jhh.1002244; published online 21 June 2007Matrix metalloproteinase-9 polymorphism contributes to blood pressure and arterial stiffness in essential hypertension
S Zhou1, J Feely1,2, J P Spiers1 and A Mahmud1,21Department of Pharmacology and Therapeutics, Trinity College Dublin, Dublin, Ireland2Hypertension Clinic, St James’s Hospital, Dublin, Ireland
Correspondence: Dr A Mahmud, Department of Pharmacology [...]

Endothelial cells of human colorectal cancer and healthy colon reveal phenotypic differences in culture

Laboratory Investigation (2007) 87, 1159–1170; doi:10.1038/labinvest.3700671; published online 17 September 2007
 
Endothelial cells of human colorectal cancer and healthy colon reveal phenotypic differences in culture
 
Vera Simone Schellerer1,2, Roland Siegfried Croner1, Kristina Weinländer2, Werner Hohenberger1, Michael Stürzl2 and Elisabeth Naschberger2

1Department of Surgery, Friedrich-Alexander University, Erlangen, Germany
2Division of Molecular and Experimental Surgery, Department of Surgery, Friedrich-Alexander University, Erlangen, [...]

ROCK-II mediates colon cancer invasion via regulation of MMP-2 and MMP-13 at the site of invadopodia as revealed by multiphoton imaging

Laboratory Investigation (2007) 87, 1149–1158; doi:10.1038/labinvest.3700674; published online 17 September 2007
ROCK-II mediates colon cancer invasion via regulation of MMP-2 and MMP-13 at the site of invadopodia as revealed by multiphoton imaging
Ramana Vishnubhotla1,*, Shan Sun1,*, Jameela Huq1, Marinka Bulic2, Anil Ramesh2, Grace Guzman3, Michael Cho1 and Sarah C Glover1,2,4

1Department of Bioengineering, University of Illinois at Chicago, [...]